Keywords
Allergenic capacity
Pollen grains
Artocarpus communis
Cecropia peltata
Fraxinus uhdei
Allergic rhinitis
How to Cite
Abstract
Objective: To evaluate the frequency of IgE sensitization and allergenic capacity of pollen grains of Artocarpus communis, Cecropia peltata and Fraxinus uhdei in allergic rhinitis patients.
Methods: A cross-sectional study with comparative groups: a rhinitis group and a control group. The three pollen extracts were prepared, and IgE sensitization was assessed using the skin prick test and serum-specific IgE. Allergenicity and clinical relevance were subsequently evaluated using the basophil activation test (BAT) and the nasal challenge test (NCT).
Results: A total of 60 people were included in the control group and 60 in the case group. None in the control group and a total of 8 (13.3%) from the rhinitis group were sensitized to one of the 3 pollen extracts: two (3.3%) to A. communis, two (3.3%) to C. peltata and four (6.6%) to F. uhdei. All three extracts were able to induce basophil activation in patients with IgE sensitization, but not in those without sensitization. NCT was performed in the eight patients with IgE sensitization, resulting positive for 1/2 patients with Artocarpus, 1/2 with Cecropia y 2/4 with Fraxinus.
Conclusion: All three pollen sources tested induce IgE sensitization and clinical symptoms, highlighting the importance of evaluating the allergenicity of native plant sources for each region.
Keywords: IgE; Allergenic capacity; Pollen grains; Artocarpus communis; Cecropia peltata; Fraxinus uhdei; Allergic rhinitis.
References
1. Tirella PN, Craig RL, Tubbs DB, Olson NE, et al. Extending surface enhanced Raman spectroscopy (SERS) of atmospheric aerosol particles to the accumulation mode (150-800 nm). Environ Sci Process Impacts 2018; 20 (11): 1570-80.
2. Parshintsev J, Hyötyläinen T. Methods for characterization of organic compounds in atmospheric aerosol particles. Anal Bioanal Chem 2015; 407 (20): 5877-97.
3. D'Amato G, Chong-Neto HJ, Monge Ortega OP, Vitale C, et al. The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens. Allergy 2020; 75 (9): 2219-28.
4. Myszkowska D, Bogawski P, Piotrowicz K, Bosiacka B, et al. Co-exposure to highly allergenic airborne pollen and fungal spores in Europe. Sci Total Environ 2023; 905: 167285.
5. Biedermann T, Winther L, Till SJ, Panzner P, Knulst A, et al. Birch pollen allergy in Europe. Allergy 2019; 74 (7): 1237-48.
6. D'Amato G, Cecchi L, Bonini S, Nunes C, et al. Allergenic pollen and pollen allergy in Europe. Allergy 2007; 62 (9): 976-90.
7. Sánchez J, Diez LS, Álvarez L, Munera M, et al. Changes in Prevalence of IgE Sensitization and Allergenic Exposition over a 10-Year Period in a Tropical Region. Int Arch Allergy Immunol 2024: 1-11.
8. Caraballo L, Zakzuk J, Lee BW, Acevedo N, et al. Particularities of allergy in the Tropics. World Allergy Organ J 2016; 9: 20.
9. Alzate F, Quijano MQ, Alvarez A, Fonnegra R. Atmospheric pollen and spore content in the urban area of the city of Medellin, Colombia. Hoehnea 2015; 42 (1).
10. Espinosa-Correa Á, Maya-Manzano JM, Alzate-Guarín FA. Airborne pollen concentrations overpass expectations in the tropical city of Medellín, Colombia. Sci Total Environ 2025; 958: 178066.
11. Sánchez J, Sánchez A. Differences in the Nasal Inflammatory Response to. Allergy Rhinol (Providence) 2018; 9: 2152656718815870.
12. Sánchez J, Caraballo L. Impact of air pollution on the development of asthma. Rev Alerg Mex 2015; 62 (4): 287-301.
13. Alzate-Guarín F, Quijano M, AÁlvarez A, Fonnegra R. Atmospheric pollen and spore content in the urban area of the city of Medellin, Colombia. Hoehnea 2015; 41 (1).
14. SanchezSánchez J, Díiez S, Cardona R. Sensibilización a aeroalergenos en pacientes alérgicos de Medellín, Colombia Rev Alergia Méx 2012; 59 (3): 139-47.
15. Baiardini I, Braido F, Tarantini F, Porcu A, et al. ARIAsuggested drugs for allergic rhinitis: what impact on quality of life? A GA2LEN review. Allergy 2008; 63 (6): 660-9.
16. Bousquet J, Heinzerling L, Bachert C, Papadopoulos NG, et al. Practical guide to skin prick tests in allergy to aeroallergens. Allergy 2012; 67 (1): 18-24.
17. Sánchez J, Sánchez Biol A, Múnera Biol M, García E, López JF. Immunoglobulin E and G autoantibodies against eosinophil proteins in children and adults with asthma and healthy subjects. World Allergy Organ J 2023; 16 (2): 100742.
18. Sánchez J, Sánchez A, Munera M, GarciaGarcía E, et al. Presence of IgE Autoantibodies Against Eosinophil Peroxidase and Eosinophil Cationic Protein in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis. Allergy Asthma Immunol Res 2021; 13 (5): 746-61.
19. Ye YM, Yang EM, Yoo HS, Shin YS, et al. Increased level of basophil CD203c expression predicts severe chronic urticaria. J Korean Med Sci 2014; 29 (1): 43-7.
20. Sánchez A, Caraballo A, AlvarezÁlvarez L, Valencia O, et al. Molecular characteristics of atopic dermatitis patients with clinical remission. World Allergy Organ J 2024; 17 (11): 100983.
21. Santamaría L, Calle A, Tejada-Giraldo Biol M, Calvo V, et al. Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis. World Allergy Organ J 2020; 13 (9): 100461.
22. Augé J, Vent J, Agache I, Airaksinen L, et al. EAACI Position paper on the standardization of nasal allergen challenges. Allergy 2018; 73 (8): 1597-608.
23. Dordal MT, Lluch-Bernal M, Sánchez MC, Rondón C, et al. Allergen-specific nasal provocation testing: review by the rhinoconjunctivitis committee of the Spanish Society of Allergy and Clinical Immunology. J Investig Allergol Clin Immunol 2011; 21 (1): 1-12; quiz follow
24. Pértegas S, Pita S. Cálculo del tamaño muestral en estudios de casos y controles. Cad Aten Primaria 2002; 9: 148-50.
25. Dennis RJ, Caraballo L, García E, Rojas MX, et al. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study. BMC Pulm Med 2012; 12: 17.
26. Zakzuk J, Jiménez S, Cheong N, Puerta L, et al. Immunological characterization of a Blo t 12 isoallergen: identification of immunoglobulin E epitopes. Clin Exp Allergy 2009; 39 (4): 608-16.
27. Verscheure P, Honnay O, Speybroeck N, Daelemans R, et al. Impact of environmental nitrogen pollution on pollen allergy: A scoping review. Sci Total Environ 2023; 893: 164801.
28. Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, et al. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101. PLoS One 2014; 9 (8): e104520.
29. Bansal RPP, Sanghvi M, Bansal A. Jackfruit allergy-An increasing exotic problem linked to the oral allergy syndrome. Austin J Allergy 2018; 1 (5): 1032-5.
30. Bolhaar ST, Ree R, Bruijnzeel-Koomen CA, Knulst AC, et al. Allergy to jackfruit: a novel example of Bet v 1-related food allergy. Allergy 2004; 59 (11): 1187-92.
31. Hemmer W, Focke M, Marzban G, Swoboda I, et al. Identification of Bet v 1-related allergens in fig and other Moraceae fruits. Clin Exp Allergy 2010; 40 (4): 679-87.
32. Iddagoda J, Gunasekara P, Handunnetti S, Jeewandara C, et al. Identification of allergens in Artocarpus heterophyllus, Moringa oleifera, Trianthema portulacastrum and Syzygium samarangense. Clin Mol Allergy 2023; 21 (1): 6.
33. RodriguezRodríguez A, Leal F. Caracterización bioquímica parcial de proteínas alergénicas de fraxinus sinensis y Cecropia sp. Universitas Scientiarum 1997; 4 (1): 57-70.
34. Vara A, Fernández-González M, Aira MJ, Rodríguez-Rajo FJ. Fraxinus pollen and allergen concentrations in Ourense (South-western Europe). Environ Res 2016; 147: 241-8.
35. Hemmer W, Focke M, Wantke F, Götz M, et al. Ash (Fraxinus excelsior) pollen allergy in central Europe: specific role of pollen panallergens and the major allergen of ash pollen, Fra e 1. Allergy 2000; 55 (10): 923-30.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2025 Revista Alergia México