<b>Asthma mortality in Colombia: A three-decade analysis and the effect of the COVID-19 Pandemic.</b>
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Keywords

Asthma
COVID-19
Global Burden of Disease
Prevalence
Colombia
Chronic diseases
Public health
Emergency

How to Cite

Asthma mortality in Colombia: A three-decade analysis and the effect of the COVID-19 Pandemic. (2026). Revista Alergia México, 73(2), 137-152. https://doi.org/10.29262/ram.v73i2.1597

Abstract

OBJECTIVES: To describe asthma mortality trends in Colombia from 1990 to 2021 and to assess the impact of the COVID-19 pandemic during the 2020-2021 period.

METHODS: Retrospective and observational study, carried out from the analysis of Global Burden of Disease 2021 were used to estimate age-standardized prevalence, mortality, and disability-adjusted life years (DALYs) for asthma in Colombia. Additionally, crude asthma mortality data for the period 2015–2023 were obtained from the National Department of Statistics of Colombia (DANE). Temporal trends were assessed using Joinpoint regression, and crude mortality rates before and during the COVID-19 pandemic were compared to estimate excess mortality.

RESULTS: A significant decline in asthma mortality was observed in Colombia between 1990 and 2021 (average annual percent change [AAPC]: −1.5%; 95%CI: −1.7 to −1.3), consistent with global trends. However, during 2020–2021, asthma-related mortality in Colombia increased from 0.43 to 0.63 per 100,000 population compared with the 2015–2019 period (RR = 1.49; 95% CI: 1.35–1.64), with a greater relative increase among individuals older than 65 years.

CONCLUSIONS: Despite sustained reductions in asthma mortality over three decades in Colombia, the COVID-19 pandemic was associated with a substantial increase in asthma-related deaths, highlighting the importance of maintaining continuity of care for chronic diseases during public health emergency.

KEYWORDS: Asthma; COVID-19 pandemic; Global Burden of Disease; Prevalence; Colombia; Chronic diseases; Public health; Emergency.

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References

1. Cao Y, Chen S, Chen X, Zou W, et al. Global trends in the incidence and mortality of asthma from 1990 to 2019: An age-period-cohort analysis using the global burden of disease study 2019. Front Public Health 2022; 10: 1036674. https://doi.org/10.3389/fpubh.2022.1036674.

2. GBD 2021 Asthma and Allergic Diseases Collaborators. Global, regional, and national burden of asthma and atopic dermatitis, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Respir Med 2025; 13: 425-46. https://doi.org/10.1016/S2213-2600(25)00003-7.

3. Ye W, Xu X, Ding Y, Li X, et al. Trends in disease burden and risk factors of asthma from 1990 to 2019 in Belt and Road Initiative countries: evidence from the Global Burden of Disease Study 2019. Ann Med 2024; 56: 2399964. https://doi.org/10.1080/07853890.2024.2399964.

4. Pizzichini MMM, Cruz ÁA, Pizzichini E. Is asthma mortality decreasing or increasing in Brazil? The burden of proof. J Bras Pneumol 2024; 50: e20240355. https://doi.org/10.36416/1806-3756/e20240355.

5. Msemburi W, Karlinsky A, Knutson V, Aleshin-Guendel S, et al. The WHO estimates of excess mortality associated with the COVID-19 pandemic. Nature 2023; 613: 130-7. https://doi.org/10.1038/s41586-022-05522-2.

6. Wang H, Paulson KR, Pease SA, Watson S, et al. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet 2022; 399: 1513-36. https://doi.org/10.1016/S0140-6736(21)02796-3.

7. Ren J, Pang W, Luo Y, Cheng D, et al. Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality. J Allergy Clin Immunol Pract 2022; 10: 124-33. https://doi.org/10.1016/j.jaip.2021.10.049.

8. Sunjaya AP, Allida SM, Di Tanna GL, Jenkins CR. Asthma and COVID-19 risk: a systematic review and meta-analysis. Eur Respir J 2022; 59: 2101209. https://doi.org/10.1183/13993003.01209-2021.

9. Ferrari AJ, Santomauro DF, Aali A, Abate YH, et al. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 2024; 403: 2133-61. https://doi.org/10.1016/S0140-6736(24)00757-8.

10. DANE. Births and Deaths 2025;https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/nacimientos-y-defunciones.

11. Population projections 2025. www.dane.gov.co/index.php/en/statistics-by-topic-1/population-and-demography/population-projections.

12. Kim H-J, Chen H-S, Byrne J, Wheeler B, Feuer EJ. Twenty years since Joinpoint 1.0: Two major enhancements, their justification, and impact. Stat Med 2022; 41: 3102-30. https://doi.org/10.1002/sim.9407.

13. Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000; 19: 335-51. https://doi.org/10.1002/(sici)1097-0258(20000215)19:3%253C335::aid-sim336%253E3.0.co;2-z.

14. Tapper EB, Parikh ND. Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. BMJ 2018; 362: k2817. https://doi.org/10.1136/bmj.k2817.

15. Vergara C, Caraballo L. Asthma mortality in Columbia. Ann Allergy Asthma Immunol 1998; 80: 55-60. https://doi.org/10.1016/s1081-1206(10)62940-7.

16. Gyawali B, Georas SN, Khurana S. Biologics in severe asthma: a state-of-the-art review. Eur Respir Rev 2025; 34: 240088. https://doi.org/10.1183/16000617.0088-2024.

17. Neto AC, Filho OFF, Bueno T. Brazilian examples of programs for the control of asthma. J Bras Pneumol 2008; 34: 103-6. https://www.scielo.br/j/jbpneu/a/j8vgpqhbkdNQg3whVT9VzcB/?lang=pt

18. Departamento Nacional de Planeación. Population Health Coverage in Colombia 2018. https://www.dnp.gov.co/LaEntidad_/subdireccion-general-prospectiva-desarrollo-nacional/direccion-desarrollo-social/Paginas/aseguramiento-de-poblacion.aspx.

19. Urrutia-Pereira M, Chong-Neto HJ, Annesi Maesano I, Ansotegui IJ, et al. Environmental contributions to the interactions of COVID-19 and asthma: A secondary publication and update. World Allergy Organ J 2022; 15: 100686. https://doi.org/10.1016/j.waojou.2022.100686.

20. Kang Q, Yau YK, Hu Z, Quan J, et al. The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis. J Evid Based Med 2025; 18: e70039. https://doi.org/10.1111/jebm.70039.

21. Stadhouders L, Hoogteijling EM, Duijts L, Lebon A. Trends in asthma exacerbations in children before, during, and after the COVID-19 pandemic. Epidemiol Infect 2025; 153: e138. https://doi.org/10.1017/S0950268825100800.

22. Brum M, Henz J, Boeira M, Soares S, Friedrich F, Pitrez PM. Recent increase in asthma mortality in Brazil: a warning sign for the public health system. J Bras Pneumol 2024; 50: e20240138. https://doi.org/10.36416/1806-3756/e20240138.

23. Pinheiro DHA, Souza JVH de, Justo AFO, Carvalho-Pinto RM, et al. Asthma in the Brazilian Unified Health Care System: an epidemiological analysis from 2008 to 2021. J Bras Pneumol 2024; 50: e20230364. https://doi.org/10.36416/1806-3756/e20230364.

24. Kamal BJ, Khalaf MA. Impact of COVID-19 on asthma control in Kirkuk City: an analysis of post-pandemic trends. J Med Life 2024; 17: 292-5. https://doi.org/10.25122/jml-2023-0175.

25. Wang L, Foer D, Zhang Y, Karlson EW, et al. Post-Acute COVID-19 Respiratory Symptoms in Patients With Asthma: An Electronic Health Records-Based Study. J Allergy Clin Immunol Pract 2023; 11: 825-835.e3. https://doi.org/10.1016/j.jaip.2022.12.003.

26. Kabil NK, Karadoğan D, Telatar TG, Kaya İ, et al. Post-COVID-19 Physical Activity and Symptom Burden in Patients with Asthma and COPD Compared with Individuals Without Chronic Disease: A Multicenter Cross-Sectional Study. Diagnostics 2026; 16. https://doi.org/10.3390/diagnostics16040604.

27. Hung C-T, Hung Y-C, Suk C-W, Wu C-H. Evaluating the associations among asthma, asthma control and long COVID in U.S. adults. Infection 2025; 53: 2523-31. https://doi.org/10.1007/s15010-025-02588-8.

28. Lozano A, Salcedo-Mejia F, Dueñas C, Fernandez JC, et al. Prevalence of post-COVID symptoms in a cohort of hospitalized patients in the North Coast of Colombia (Pre-print) 2024. https://doi.org/10.21203/rs.3.rs-3898490/v1.

29. Patel O, Syamlal G, Wood J, Dodd KE, et al. Asthma Mortality Among Persons Aged 15-64 Years, by Industry and Occupation - United States, 1999-2016. MMWR Morb Mortal Wkly Rep 2018; 67: 60-65. https://doi.org/10.15585/mmwr.mm6702a2.

30. Orozco-Levi M, Borrero L, Botero L, Londoño S, Saenz S. Distribución de la prevalencia de asma registrada en Colombia. Rev Colombiana Neumol 2023. https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/821.

31. Bhuia MR, Islam MA, Nwaru BI, Weir CJ, et al. Models for estimating and projecting global, regional and national prevalence and disease burden of asthma: a systematic review. J Glob Health 2020; 10: 020409. https://doi.org/10.7189/jogh.10.020409.

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