Vol. 71 No. 2 (2024), Case clinical reports
Vol. 71 No. 2 (2024)

Allergic contact dermatitis due to Furacin®

Case clinical reports
Published 2024-04-30
Lucía Moreno Lozano
Alergología
Teresa de Aramburu Mera
Facultativa especialista de área en alergología
Carmen Bermúdez Hormigo
Facultativa especialista de área en alergología
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Keywords

Allergic sensitisation to topical antimicrobial treatments is a well-known problem. Furacin is one of the most widely used in our environment. It contains 0.2% nitrofurazone and polyethylene glycol (PEG) as a vehicle. Case description: 57-year-old male with no past history of interest. He presented skin rash, blisters and serous exudate 2-3 days after starting treatment with Furacin (applied to an infected skin wound). Epicutaneous tests were performed with a true true test battery, nitrofurantoin 1% in petrolatum, PEG15000 and 4000 1% in petrolatum, pure PEG 400, PEG monomethyl ether 350 1% in water. Positive result at 96 hours for nitrofurantoin. Discussion: Nitrofurazone is widely used as a topical antibiotic because of its bactericidal spectrum. It (including its excipients) should be taken into account in case of adverse reactions after application.
dermatitis

How to Cite

Allergic contact dermatitis due to Furacin®. (2024). Revista Alergia México, 71(2), 128-130. https://doi.org/10.29262/ram.v71i2.1246
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Abstract

Background: Allergic sensitization to topical antimicrobial treatments is a well-known problem. Furacin® is one of the most widely used in our environment. It contains 0.2% nitrofurazone and polyethylene glycol (PEG) as a vehicle.

Case report: 57-year-old male with no history of interest. He presented skin rash, blisters, and serous exudate 2-3 days after starting treatment with Furacin® (applied to an infected skin wound). Epicutaneous tests were performed with a true test battery, nitrofurantoin 1% in petrolatum, PEG15000 and 4000 1% in petrolatum, pure PEG 400, PEG monomethyl ether 350 1% in water. Positive result at 96 hours for nitrofurantoin.

Conclusion: Nitrofurazone is widely used as a topical antibiotic because of its bactericidal spectrum. It (including its excipients) should be considered in case of adverse reactions after application.

Keywords: Dermatitis; Nitrofurazone; Topical antibiotics.

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References

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Prieto A, Baeza ML, Herrero T et al. Contact dermatitis to Furacin. Contact Dermatitis. 2006; 54: 126

Downing JG, Brecker FW. Further studies in the use of furacin in dermatology. N Engl J Med 1948; 239: 862-4.

Bilgili SG, Ozaydin-Yavuz G, Yavuz IH, Bilgili MA, et al. Cutaneous reactions caused by nitrofurazone. Postepy Dermatol Alergol 2019; 36: 398-402.

Claudia-Conejero I, Leire L, Hervella M. Contact dermatitis caused by polyethylene glycol-7 monooleate. Contact Dermatitis 2015; 72 (3): 185-6.

Özkaya E, Kılıç S. Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey. Contact Dermatitis. 2018; 78 (3): 211-215. doi: 10.1111/cod.12931.

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